FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer.
Oluwademilade O DairoLia DePaula OliveiraEthan D SchafferThiago VidottoAdrianna A A MendesJiayun LuSophie Vo HuynhJessica L HicksAdam G SowalskyAngelo M DeMarzoCorrine E JoshuBrian HanrattyKaren S SfanosWilliam B IsaacsMichael C HaffnerTamara L LotanPublished in: Cancer research communications (2024)
Here, we leverage multiple independent primary and metastatic prostate cancer cohorts to demonstrate that FASN gene body methylation is highly inversely correlated with FASN gene and protein expression. This finding may shed light on epigenetic mechanisms of FASN regulation in prostate cancer and provides a potentially useful biomarker for selecting patients in future trials of FASN inhibitors.
Keyphrases
- prostate cancer
- genome wide
- copy number
- radical prostatectomy
- dna methylation
- end stage renal disease
- fatty acid
- genome wide identification
- chronic kidney disease
- ejection fraction
- newly diagnosed
- poor prognosis
- squamous cell carcinoma
- gene expression
- peritoneal dialysis
- prognostic factors
- genome wide analysis
- patient reported
- transcription factor