Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis.
Alexandra SnyderTavi NathansonSamuel A FuntArun AhujaJacqueline BurosMatthew D HellmannEliza ChangBülent Arman AksoyHikmat Al-AhmadieErik YuskoMarissa VignaliSharon BenzenoMariel BoydMeredith MoranGopa IyerHarlan S RobinsElaine R MardisTaha MerghoubJeff HammerbacherJonathan E RosenbergDean F BajorinPublished in: PLoS medicine (2017)
These results demonstrate the complex nature of immune response to checkpoint blockade and the compelling need for greater interrogation and data integration of both host and tumor factors. Incorporating these variables in prospective studies will facilitate identification and treatment of resistant patients.