Lipid metabolism-related lncRNA SLC25A21-AS1 promotes the progression of oesophageal squamous cell carcinoma by regulating the NPM1/c-Myc axis and SLC25A21 expression.

Yu LiuChunxiang LiLingling FangLiyu WangHengchang LiuHe TianYujia ZhengTao Fan Jie He

Published in: Clinical and translational medicine (2022)

HFD/PA has an inhibitory effect on ESCC cells and SLC25A21-AS1 expression. SLC25A21-AS1 promotes the proliferation and migration of ESCC cells by regulating the NPM1/c-Myc axis and SLC25A21 expression. In addition, lncRNA SLC25A21-AS1 may serve as a favourable prognostic biomarker and a potential therapeutic target for ESCC.

Keyphrases

poor prognosis
induced apoptosis
squamous cell carcinoma
acute myeloid leukemia
long non coding rna
cell cycle arrest
binding protein
high fat diet
cell death
oxidative stress
long noncoding rna
metabolic syndrome
adipose tissue
fatty acid
drug induced