Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer's disease.
Lutgarde SerneelsDries T'SyenLaura Perez-BenitoTom TheysMatthew G HoltBart De StrooperPublished in: Molecular neurodegeneration (2020)
The different humanized APP models (rat and mouse) expressing human Aβ and PSEN1 M139T are valuable controls to study APP processing in vivo allowing the use of a human Aβ ELISA which is more sensitive than the equivalent system for rodents. These animals will be made available to the research community.