Bart De Strooper (Bart de Strooper)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 37

Top Topics

Inflammatory Response

Cognitive Decline

Lipopolysaccharide Induced

Top Venues

The EMBO journal

Nature neuroscience

Acta neuropathologica

EMBO molecular medicine

This page only lists publications with an associated author ORCID identifier.

Publications

Bart De Strooper, Eric Karran
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases. The EMBO journal 43 (6) (2024)
Bart De Strooper, Eric Karran
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases. The EMBO journal 43 (6) (2024)
Sriram Balusu, Bart De Strooper
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disease. Acta neuropathologica 147 (1) (2024)
Sriram Balusu, Bart De Strooper
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disease. Acta neuropathologica 147 (1) (2024)
Sriram Balusu, Bart De Strooper
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disease. Acta neuropathologica 147 (1) (2024)
Bart De Strooper, Eric Karran
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases. The EMBO journal (2024)
Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco, Baukje Bijnens, Pranav Preman, Lutgarde Serneels, Suresh Poovathingal, Sriram Balusu, Catherine M Verfaillie, Mark Fiers, Bart De Strooper
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology. Nature neuroscience 27 (5) (2024)
Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco, Baukje Bijnens, Pranav Preman, Lutgarde Serneels, Suresh Poovathingal, Sriram Balusu, Catherine M Verfaillie, Mark Fiers, Bart De Strooper
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology. Nature neuroscience 27 (5) (2024)
Bart De Strooper, Eric Karran
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases. The EMBO journal 43 (6) (2024)
Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco, Baukje Bijnens, Pranav Preman, Lutgarde Serneels, Suresh Poovathingal, Sriram Balusu, Catherine M Verfaillie, Mark Fiers, Bart De Strooper
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology. Nature neuroscience 27 (5) (2024)
Sriram Balusu, Bart De Strooper
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disease. Acta neuropathologica 147 (1) (2024)
Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco, Baukje Bijnens, Pranav Preman, Lutgarde Serneels, Suresh Poovathingal, Sriram Balusu, Catherine M Verfaillie, Mark Fiers, Bart De Strooper
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology. Nature neuroscience 27 (5) (2024)
Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco, Baukje Bijnens, Pranav Preman, Lutgarde Serneels, Suresh Poovathingal, Sriram Balusu, Catherine M Verfaillie, Mark Fiers, Bart De Strooper
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology. Nature neuroscience 27 (5) (2024)
Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco, Baukje Bijnens, Pranav Preman, Lutgarde Serneels, Suresh Poovathingal, Sriram Balusu, Catherine M Verfaillie, Mark Fiers, Bart De Strooper
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology. Nature neuroscience (2024)
Sara Calafate, Gökhan Özturan, Nicola Thrupp, Jeroen Vanderlinden, Luísa Santa-Marinha, Rafaela Morais-Ribeiro, Antonella Ruggiero, Ivan Bozic, Thomas Rusterholz, Blanca Lorente-Echeverría, Marcelo Dias, Wei-Ting Chen, Mark Fiers, Ashley Lu, Ine Vlaeminck, Eline Creemers, Katleen Craessaerts, Joris Vandenbempt, Luuk van Boekholdt, Suresh Poovathingal, Kristofer Davie, Dietmar Rudolf Thal, Keimpe Wierda, Tiago Gil Oliveira, Inna Slutsky, Antoine R Adamantidis, Bart De Strooper, Joris de Wit
Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease. Nature neuroscience (2023)
Sriram Balusu, Katrien Horré, Nicola Thrupp, Katleen Craessaerts, An Snellinx, Lutgarde Serneels, Dries T'Syen, Iordana Chrysidou, Amaia M Arranz, Annerieke Sierksma, Joel Simrén, Jonathan M Schott, Henrik Zetterberg, Wei-Ting Chen, Dietmar Rudolf Thal, Evgenia Salta, Mark Fiers, Bart De Strooper
MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease. Science (New York, N.Y.) 381 (6663) (2023)
Eric Karran, Bart De Strooper
The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics. Nature reviews. Drug discovery 21 (4) (2022)
Liesbeth Aerts, Beatrice Miccoli, Aaron Delahanty, Hilda Witters, Sandra Verstraelen, Bart De Strooper, Dries Braeken, Patrik Verstreken
Do we still need animals? Surveying the role of animal-free models in Alzheimer's and Parkinson's disease research. The EMBO journal 41 (6) (2022)
Marika Marino, Lujia Zhou, Melvin Y Rincon, Zsuzsanna Callaerts-Vegh, Jens Verhaert, Jérôme Wahis, Eline Creemers, Lidia Yshii, Keimpe Wierda, Takashi Saito, Catherine Marneffe, Iryna Voytyuk, Yessica Wouters, Maarten Dewilde, Sandra I Duqué, Cécile Vincke, Yona Levites, Griffin Golde, Takaomi C Saido, Serge Muyldermans, Adrian Liston, Bart De Strooper, Matthew G Holt
AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model. EMBO molecular medicine 14 (4) (2022)
Tengyuan Liu, Tingting Zhang, Maya Nicolas, Lydie Boussicault, Heather Rice, Alessia Soldano, Annelies Claeys, Iveta Petrova, Lee Fradkin, Bart De Strooper, Marie-Claude Potier, Bassem A Hassan
The amyloid precursor protein is a conserved Wnt receptor. eLife 10 (2021)
Giovanna Lalli, Jonathan M Schott, John A Hardy, Bart De Strooper
Aducanumab: a new phase in therapeutic development for Alzheimer's disease? EMBO molecular medicine 13 (8) (2021)
Nicola Fattorelli, Anna Martinez-Muriana, Leen Wolfs, Ivana Geric, Bart De Strooper, Renzo Mancuso
Stem-cell-derived human microglia transplanted into mouse brain to study human disease. Nature protocols 16 (2) (2021)
Ganna Leonenko, Emily Simmonds, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart De Strooper, Valentina Escott-Price
Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores. Nature communications 12 (1) (2021)
Roger A Habets, Charles E de Bock, Lutgarde Serneels, Inge Lodewijckx, Delphine Verbeke, David Nittner, Rajeshwar Narlawar, Sofie Demeyer, James Dooley, Adrian Liston, Tom Taghon, Jan Cools, Bart De Strooper
Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition. Science translational medicine 11 (494) (2020)
Annerieke Sierksma, Valentina Escott-Price, Bart De Strooper
Translating genetic risk of Alzheimer's disease into mechanistic insight and drug targets. Science (New York, N.Y.) 370 (6512) (2020)
Lutgarde Serneels, Dries T'Syen, Laura Perez-Benito, Tom Theys, Matthew G Holt, Bart De Strooper
Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer's disease. Molecular neurodegeneration 15 (1) (2020)
Annerieke Sierksma, Ashley Lu, Renzo Mancuso, Nicola Fattorelli, Nicola Thrupp, Evgenia Salta, Jesús Zoco, David Blum, Luc Buée, Bart De Strooper, Mark Fiers
Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology. EMBO molecular medicine 12 (3) (2020)
Heather C Rice, Gabriele Marcassa, Iordana Chrysidou, Katrien Horré, Tracy L Young-Pearse, Ulrike C Müller, Takashi Saito, Takaomi C Saido, Robert Vassar, Joris de Wit, Bart De Strooper
Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model. Molecular neurodegeneration 15 (1) (2020)
Marta J Koper, Evelien Van Schoor, Simona Ospitalieri, Rik Vandenberghe, Mathieu Vandenbulcke, Christine A F von Arnim, Thomas Tousseyn, Sriram Balusu, Bart De Strooper, Dietmar Rudolf Thal
Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer's disease. Acta neuropathologica 139 (3) (2019)
Sonja M Sachse, Sam Lievens, Luís F Ribeiro, Dan Dascenco, Delphine Masschaele, Katrien Horré, Anke Misbaer, Nele Vanderroost, Anne Sophie De Smet, Evgenia Salta, Maria-Luise Erfurth, Yoshiaki Kise, Siegfried Nebel, Wouter Van Delm, Stéphane Plaisance, Jan Tavernier, Bart De Strooper, Joris De Wit, Dietmar Schmucker
Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation. The EMBO journal 38 (6) (2019)
Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli, Leen Wolfs, Sriram Balusu, Oliver T Burton, Adrian Liston, Annerieke Sierksma, Yannick Fourne, Suresh Poovathingal, Amaia Arranz-Mendiguren, Carlo Sala Frigerio, Christel Claes, Lutgarde Serneels, Tom Theys, V Hugh Perry, Catherine Verfaillie, Mark Fiers, Bart De Strooper
Stem-cell-derived human microglia transplanted in mouse brain to study human disease. Nature neuroscience 22 (12) (2019)
Hermien Acx, Lutgarde Serneels, Enrico Radaelli, Serge Muyldermans, Cécile Vincke, Elise Pepermans, Ulrike Müller, Chávez-Gutiérrez Lucía, Bart De Strooper
Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration. EMBO molecular medicine 9 (8) (2018)
Iryna Voytyuk, Stephan A Mueller, Julia Herber, An Snellinx, Dieder Moechars, Geert van Loo, Stefan F Lichtenthaler, Bart De Strooper
BACE2 distribution in major brain cell types and identification of novel substrates. Life science alliance 1 (1) (2018)
Melissa Vos, Ann Geens, Claudia Böhm, Liesbeth Deaulmerie, Jef Swerts, Matteo Rossi, Katleen Craessaerts, Elvira P Leites, Philip Seibler, Aleksandar Rakovic, Thora Lohnau, Bart De Strooper, Sarah-Maria Fendt, Vanessa A Morais, Christine Klein, Patrik Verstreken
Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency. The Journal of cell biology 216 (3) (2017)
Hiroki Sasaguri, Per Nilsson, Shoko Hashimoto, Kenichi Nagata, Takashi Saito, Bart De Strooper, John A Hardy, Robert Vassar, Bengt Winblad, Takaomi C Saido
APP mouse models for Alzheimer's disease preclinical studies. The EMBO journal 36 (17) (2017)
Evgenia Salta, Annerieke Sierksma, Elke Vanden Eynden, Bart De Strooper
miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO molecular medicine 8 (9) (2016)
Lucía Chávez-Gutiérrez, Bart De Strooper
Probing γ-secretase-substrate interactions at the single amino acid residue level. The EMBO journal 35 (15) (2016)