The metabolome of individuals with knee osteoarthritis is influenced by 18-months of an exercise and weight loss intervention and sex: the IDEA trial.
Hope D WelhavenAvery H WefleyBrian BothnerStephen P MessierRichard F LoeserRonald K JunePublished in: bioRxiv : the preprint server for biology (2024)
These findings suggest that intensive weight loss among male and female subjects offers potential metabolic benefits for individuals with knee OA. This provides a deeper understanding of dysregulation occurring during OA development that may pave the way for improved interventions, treatments, and quality of life of those impacted by this disease.
Keyphrases
- knee osteoarthritis
- weight loss
- bariatric surgery
- roux en y gastric bypass
- physical activity
- gastric bypass
- randomized controlled trial
- study protocol
- clinical trial
- high intensity
- phase iii
- glycemic control
- phase ii
- weight gain
- body mass index
- adipose tissue
- open label
- insulin resistance
- placebo controlled
- double blind