Octamer 4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells.

Stella ChaiKai-Yu NgMan TongEunice Y LauTerence K LeeKwok Wah ChanYun-Fei YuanTan-To CheungSiu-Tim CheungXiao-Qi WangNathalie WongChung-Mau LoKwan ManXin-Yuan GuanStephanie Ma

Published in: Hepatology (Baltimore, Md.) (2016)

These findings uncover the noncanonical regulation of Wnt/β-catenin in liver CSCs by the Oct4/miR-1246 signaling axis, and also provide a novel diagnostic marker as well as therapeutic intervention for HCC. (Hepatology 2016;64:2062-2076).

Keyphrases

cell proliferation
cancer stem cells
epithelial mesenchymal transition
stem cells
randomized controlled trial
long non coding rna
optical coherence tomography
long noncoding rna
diabetic retinopathy
optic nerve