Evaluating Glomerular Filtration Rate Slope as a Surrogate End Point for ESKD in Clinical Trials: An Individual Participant Meta-Analysis of Observational Data.
Morgan E GramsYingying SangShoshana H BallewKunihiro MatsushitaBrad C AstorJuan Jesus CarreroAlex R ChangLesley A InkerTimothy KenealyCsaba Pal KovesdyBrian J LeeAdeera LevinDavid NaimarkMichelle J PenaJesse D ScholdVarda ShalevJack F M WetzelsMark WoodwardRon T GansevoortAndrew S LeveyJosef CoreshPublished in: Journal of the American Society of Nephrology : JASN (2019)
Slower decline in eGFR was associated with lower risk of subsequent ESKD, even in participants with eGFR≥60 ml/min per 1.73 m2, but those with the highest risk would be expected to benefit the most.