Antitumor efficacy of dual blockade with encorafenib plus cetuximab in combination with chemotherapy in human BRAFV600E mutant colorectal cancer.

Stefania Napolitano Melanie Woods Hey Min Lee Vincenzo De Falco Giulia Martini Carminia Maria Della Corte Erika Martinelli Vincenzo Famiglietti Davide Ciardiello Amanda Anderson Natalie Wall Fowlkes Oscar Eduardo Villarreal Alexey V Sorokin Preeti Kanikarla Oluwadara Coker Van Karlyle Morris Lucia Altucci Josep Tabernero Teresa Troiani Fortunato Ciardiello Edmund S Kopetz

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

These results support the combination of cytotoxic chemotherapy and molecular targeted therapy as a promising therapeutic approach in the first-line treatment of BRAFV600E mCRC.

Keyphrases

locally advanced
endothelial cells
rectal cancer
wild type
squamous cell carcinoma
induced pluripotent stem cells
chemotherapy induced
pluripotent stem cells
single molecule
metastatic colorectal cancer