Hyperoxia is associated with a greater risk for mortality in critically ill traumatic brain injury patients than in critically ill trauma patients without brain injury.
David J DouinLayne DyllaErin L AndersonJohn D RiceConner M JacksonVikhyat S BebartaRobert T NeumannSteven G SchauerAdit A GindePublished in: Science progress (2023)
Critically ill trauma patients with a TBI spend a greater proportion of time in hyperoxia compared to those without a TBI. TBI status significantly modified the effect of hyperoxia on mortality. Prospective clinical trials are needed to better assess a possible causal relationship.
Keyphrases
- traumatic brain injury
- brain injury
- trauma patients
- clinical trial
- subarachnoid hemorrhage
- end stage renal disease
- severe traumatic brain injury
- cardiovascular events
- newly diagnosed
- chronic kidney disease
- ejection fraction
- mild traumatic brain injury
- prognostic factors
- type diabetes
- peritoneal dialysis
- cerebral ischemia
- randomized controlled trial
- coronary artery disease
- phase ii