Undernutrition upregulated PD-1 and PD-L1 expression and downregulated immune signaling pathways in mice with visceral leishmaniasis. The signaling pathways and hub genes may serve as drug targets or intervention targets for the treatment of leishmaniasis patients with undernutrition.
Keyphrases
- signaling pathway
- pi k akt
- high fat diet induced
- induced apoptosis
- epithelial mesenchymal transition
- randomized controlled trial
- cell proliferation
- bioinformatics analysis
- early onset
- poor prognosis
- genome wide
- network analysis
- adipose tissue
- metabolic syndrome
- combination therapy
- dna methylation
- long non coding rna
- oxidative stress
- genome wide identification
- endoplasmic reticulum stress