Personalizing treatment selection in Crohn's disease: a meta-analysis of individual participant data from fifteen randomized controlled trials.

Vivek Ashok RudrapatnaVignesh G RavindranathDouglas V Arneson Arman Mosenia Atul Janardhan Butte Shan Wang

Published in: medRxiv : the preprint server for health sciences (2023)

We found that patients do in fact harbor different underlying susceptibilities to different treatment mechanisms of action. But the biological basis of this is unknown. Future studies designed to elucidate this may reveal new therapeutic targets in Crohn's disease.

Keyphrases

end stage renal disease
randomized controlled trial
ejection fraction
newly diagnosed
chronic kidney disease
clinical trial
systematic review
genome wide
machine learning
electronic health record
peritoneal dialysis
patient reported outcomes
combination therapy
deep learning
study protocol
current status