Dietary Phospholipids Alleviate Diet-Induced Obesity in Mice: Which Fatty Acids and Which Polar Head.
Lingyu ZhangJiaqin MuJing MengWenjin SuJian LiPublished in: Marine drugs (2023)
The weight loss effects of dietary phospholipids have been extensively studied. However, little attention has been paid to the influence of phospholipids (PLs) with different fatty acids and polar headgroups on the development of obesity. High-fat-diet-fed mice were administrated with different kinds of PLs (2%, w / w ) with specific fatty acids and headgroups, including EPA-enriched phosphatidylcholine/phosphatidylethanolamine/phosphatidylserine (EPA-PC/PE/PS), DHA-PC/PE/PS, Egg-PC/PE/PS, and Soy-PC/PE/PS for eight weeks. Body weight, white adipose tissue weight, and the levels of serum lipid and inflammatory markers were measured. The expression of genes related to lipid metabolism in the liver were determined. The results showed that PLs decreased body weight, fat storage, and circulating lipid levels, and EPA-PLs had the best efficiency. Serum TNF-α, MCP-1 levels were significantly reduced via treatment with DHA-PLs and PS groups. Mechanistic investigation revealed that PLs, especially EPA-PLs and PSs, reduced fat accumulation through enhancing the expression of genes involved in fatty acid β-oxidation ( Cpt1a , Cpt2 , Cd36 , and Acaa1a ) and downregulating lipogenesis gene ( Srebp1c , Scd1 , Fas , and Acc ) expression. These data suggest that EPA-PS exhibits the best effects among other PLs in terms of ameliorating obesity, which might be attributed to the fatty acid composition of phospholipids, as well as their headgroup.
Keyphrases
- fatty acid
- body weight
- high fat diet induced
- weight loss
- insulin resistance
- high fat diet
- adipose tissue
- poor prognosis
- bariatric surgery
- metabolic syndrome
- type diabetes
- weight gain
- roux en y gastric bypass
- binding protein
- skeletal muscle
- rheumatoid arthritis
- genome wide
- physical activity
- body mass index
- multidrug resistant
- gastric bypass
- nitric oxide
- single cell
- gene expression
- long non coding rna
- deep learning
- drug induced
- dna methylation
- big data
- machine learning
- optical coherence tomography
- solid state