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Impact of renal function on the prognosis of patients receiving Atezolizumab / Bevacizumab combination therapy and Lenvatinib monotherapy for unresectable hepatocellular carcinoma.

Hitomi TakadaKoji YamashitaLeona OsawaYasuyuki KomiyamaNatsuko NakakukiMasaru MuraokaYuichiro SuzukiMitsuaki SatoShinichi TakanoMitsuharu FukasawaTatsuya YamaguchiShinya MaekawaKazuya TakahashiKohei UchimuraNobuyuki Enomoto
Published in: Oncology (2023)
In patients receiving AB and LEN therapy, baseline proteinuria was associated with OS. Renal function deterioration without proteinuria was associated with a poor prognosis in AB therapy. Excessive salt intake, pre-existing atherosclerotic disease, and drug with a high risk of renal dysfunction were risk factors for renal deterioration.
Keyphrases
  • combination therapy
  • poor prognosis
  • long non coding rna
  • weight gain
  • randomized controlled trial
  • body mass index
  • weight loss
  • cell therapy
  • metastatic colorectal cancer
  • diabetic nephropathy