Longitudinal decline in striatal dopamine transporter binding in Parkinson's disease: associations with apathy and anhedonia.

Harry Costello Yumeya Yamamori Suzanne J Reeves Anette-Eleonore Schrag Robert J Howard Jonathan Paul Roiser

Published in: Journal of neurology, neurosurgery, and psychiatry (2023)

Our findings support a central role for dopaminergic dysfunction in motivational symptoms in PD. Striatal DAT imaging may be a useful indicator of apathy/anhedonia risk that could inform intervention strategies.

Keyphrases

parkinson disease
functional connectivity
randomized controlled trial
high resolution
oxidative stress
uric acid
cross sectional
deep brain stimulation
sleep quality
metabolic syndrome
dna binding
physical activity
binding protein
prefrontal cortex
fluorescence imaging
photodynamic therapy
mass spectrometry