The functional roles of short chain fatty acids as postbiotics in human gut: future perspectives.
Mangala Lakshmi RagavanHemalatha SPublished in: Food science and biotechnology (2023)
The significance of gut microbiome and their metabolites (postbiotics) on human health could be a promising approach to treat various diseases that includes inflammatory bowel diseases, colon cancer, and many neurological disorders. Probiotics with potential mental health benefits (psychobiotics) can alter the gut-brain axis via immunological, humoral, neuronal, and metabolic pathways. Recently, probiotic bacteria like Lactobacillus and Bifidobacterium have been demonstrated for SCFAs production, which play a crucial role in a variety of diseases. These acids could enhance the production of mucins, antimicrobial proteins (bacteriocins and peptides), cytokines (Interleukin 10 and 18) and neurotransmitters (serotonin) in the intestine to main the gut microbiota, intestinal barrier system and other immune functions. In this review, we discuss about two mechanisms such as (i) SCFAs mediated intestinal barrier system, and (ii) SCFAs mediated gut-brain axis to elucidate the therapeutic options for the treatment/prevention of various diseases.
Keyphrases
- human health
- mental health
- risk assessment
- cerebral ischemia
- resting state
- fatty acid
- white matter
- endothelial cells
- immune response
- ms ms
- functional connectivity
- subarachnoid hemorrhage
- induced pluripotent stem cells
- blood brain barrier
- brain injury
- multiple sclerosis
- mental illness
- bacillus subtilis
- pluripotent stem cells