Overall survival in the UK in mycosis fungoides or Sézary syndrome cutaneous T-cell lymphoma: comparative effectiveness of mogamulizumab versus current standard of care.
Neil HawkinsNoemi MuszbekRachel EvansLinda McNamaraTrefor JonesPublished in: Journal of comparative effectiveness research (2023)
Aim: Due to extensive treatment switching in the MAVORIC trial, lack of UK regulatory licence for the comparator, overall survival (OS) with mogamulizumab was compared with patients with previously treated advanced mycosis fungoides/Sézary syndrome (MF/SS) in real-world setting. Design, setting & participants: Data were from the Hospital Episode Statistics database (all patients in NHS secondary care system in 2009-2019). Patients were selected according to trial inclusion criteria, then trial and HES samples were matched on selected variables with significant imbalance. Outcomes: The analysis indicated significant improvement in OS for mogamulizumab treatment compared with UK clinical practice (hazard ratio: 0.36, 95% CI: 0.24, 0.53). Conclusion: Results suggest an OS advantage for patients with advanced MF/SS treated with mogamulizumab in MAVORIC trial compared with UK clinical practice.
Keyphrases
- clinical practice
- study protocol
- newly diagnosed
- phase iii
- clinical trial
- end stage renal disease
- ejection fraction
- phase ii
- palliative care
- cross sectional
- randomized controlled trial
- type diabetes
- patient reported outcomes
- transcription factor
- adverse drug
- replacement therapy
- free survival
- drug induced
- smoking cessation