Study on the Mechanism of Curcumin Regulating Lung Injury Induced by Outdoor Fine Particulate Matter (PM2.5).

Kunlun HuangChanMei ShiJingQi MinLaifu LiTao ZhuHuapeng YuHuojin Deng

Published in: Mediators of inflammation (2019)

We found that PM2.5 can cause lung damage through oxidative stress and inflammatory responses. Oxidative stress and inflammatory responses increase the expression of HO-1/CO/P38 MAPK. The intervention of curcumin can further increase the expression of HO-1/CO/P38 MAPK.

Keyphrases

particulate matter
air pollution
oxidative stress
poor prognosis
randomized controlled trial
dna damage
diabetic rats
ischemia reperfusion injury
induced apoptosis
binding protein
pi k akt
long non coding rna
cell proliferation
heavy metals
polycyclic aromatic hydrocarbons
endoplasmic reticulum stress