Multicenter, Double-Blinded, Randomized, Active-Sham Controlled Clinical Study Design to Assess the Safety and Effectiveness of a Novel High Frequency Electric Nerve Block System in the Treatment of Post-Amputation Pain (The QUEST Study).
Leonardo KapuralNemath Syed ShahZi-Ping FangNagy MekhailPublished in: Journal of pain research (2022)
The QUEST study design employs an active-sham control group to objectively assess the effectiveness of HFNB therapy. Additionally, the electronic diary repeated measures data collection in QUEST is expected to reduce the intra-subject variation typically observed in pain treatment studies. Finally, the longitudinal measurement of health-related quality of life and use of pain medication may, for example, show effectiveness in reducing opioid use over time.
Keyphrases
- high frequency
- chronic pain
- double blind
- randomized controlled trial
- pain management
- systematic review
- neuropathic pain
- transcranial magnetic stimulation
- healthcare
- clinical trial
- cross sectional
- physical activity
- stem cells
- emergency department
- electronic health record
- placebo controlled
- replacement therapy
- machine learning
- big data
- phase iii
- bone marrow
- study protocol
- artificial intelligence