Obesity is an ongoing global health problem, and Cichorium glandulosum (CG, chicory) is traditionally used as a hepatoprotective and lipid-lowering drug. However, there is still a lack of research on the role of CG in the treatment of obesity. In the present study, we found that CG significantly delayed weight gain and positively affected glucolipid metabolism disorders, serum metabolism levels, and the degree of liver and kidney oxidative stress in high-fat diet (HFD) mice. Further examination of the effects of CG on intestinal microenvironmental dysregulation and its metabolites in HFD mice revealed that the CG ethanol extract high-dose group (CGH) did not have a significant regulatory effect on short-chain fatty acids. Still, CGH significantly decreased the levels of 12α-OH/non-12α-OH bile acids and also found significant upregulation of proteobacteria and downregulation of cyanobacteria at the phylum level. CG may have ameliorated obesity and metabolic abnormalities in mice by repairing gut microbiota dysbiosis and modulating bile acid biosynthesis.
Keyphrases
- high fat diet induced
- high fat diet
- insulin resistance
- weight gain
- adipose tissue
- metabolic syndrome
- oxidative stress
- weight loss
- type diabetes
- skeletal muscle
- high dose
- global health
- body mass index
- fatty acid
- signaling pathway
- birth weight
- cell proliferation
- public health
- diabetic rats
- emergency department
- dna damage
- low dose
- physical activity
- ischemia reperfusion injury
- wild type
- endoplasmic reticulum stress
- induced apoptosis
- stress induced
- mouse model
- electronic health record
- replacement therapy
- heat shock protein