Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice.
Shiwei YaoHongling LuTianhuan ZhouQihong JiangChenkai JiangWenjun HuMingqian LiChin Ping TanYongcai FengQun DuGuoxin ShenXingwei XiangLin ChenPublished in: Food & function (2024)
High-fat diet (HFD) has been associated with certain negative bone-related outcomes, such as bone metabolism disruption and bone loss. Sciadonic acid (SC), one of the main nutritional and functional components of Torreya grandis seed oil, is a unique Δ5-unsaturated-polymethylene-interrupted fatty acid (Δ5-UPIFA) that has been claimed to counteract such disorders owing to some of its physiological effects. However, the role of SC in ameliorating bone metabolism disorders due to HFD remains unclear. In the present investigation, we observed that SC modulates the OPG/RANKL/RANK signaling pathway by modifying the lipid metabolic state and decreasing inflammation in mice. In turn, it could balance bone resorption and formation as well as calcium and phosphorus levels, enhance bone strength and bone mineral density (BMD), and improve its microstructure. In addition, SC could inhibit fat vacuoles in bone, reverse the phenomenon of reduced numbers and poor continuity of bone trabeculae, and promote orderly arrangement of collagen fibers and cartilage repair. This study provides some theoretical basis for SC as a dietary intervention agent to enhance bone nutrition.
Keyphrases
- bone mineral density
- bone loss
- postmenopausal women
- high fat diet
- body composition
- soft tissue
- high fat diet induced
- fatty acid
- insulin resistance
- signaling pathway
- bone regeneration
- randomized controlled trial
- adipose tissue
- oxidative stress
- epithelial mesenchymal transition
- immune response
- risk assessment
- multiple sclerosis
- cell proliferation
- inflammatory response
- extracellular matrix
- toll like receptor
- drug induced
- fluorescent probe
- sensitive detection