Assessing the use of observational methods and real-world data to emulate ongoing randomized controlled trials.

Joshua D WallachYihong DengEric C PolleySanket S DhruvaJeph HerrinKenneth QuintoCharu GandotraWilliam CrownPeter NoseworthyXiaoxi YaoMolly Moore JefferyTimothy D LyonJoseph R RossRozalina G McCoy

Published in: Clinical trials (London, England) (2023)

Despite challenges, observational methods and real-world data can be leveraged in certain important situations for a more timely evaluation of drug effectiveness and safety in more diverse and representative patient populations.

Keyphrases

electronic health record
randomized controlled trial
cross sectional
big data
case report
clinical trial
systematic review
adverse drug
meta analyses