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A randomized pharmacokinetic and pharmacodynamic trial of two regular human insulins demonstrates bioequivalence in type 1 diabetes and availability of biosimilar insulin may improve access to this medication.

Sérgio VencioRafael Caiado-VencioLeonardo Ferreira CaixetaMałgorzata MasierekWojciech MlynarskiJózef DrzewoskiJustin M Gregory
Published in: Diabetes, obesity & metabolism (2022)
The experimental product regular human insulin and comparator Humulin® R are bioequivalent in patients with T1DM. Wider entry to the pharmaceutical market of affordable, biosimilar regular insulins may substantially improve access to insulin for many socioeconomically disadvantaged patients with diabetes.
Keyphrases
  • type diabetes
  • glycemic control
  • endothelial cells
  • induced pluripotent stem cells
  • clinical trial
  • cardiovascular disease
  • pluripotent stem cells
  • randomized controlled trial
  • phase ii
  • weight loss