Targeting inhibition of prognosis-related lipid metabolism genes including CYP19A1 enhances immunotherapeutic response in colon cancer.

Lilong LiuMin MoXuehan ChenDongchen ChaoYufan ZhangXuewei ChenYang WangNan ZhangNan HeXi YuanHonglei ChenJing Yang

Published in: Journal of experimental & clinical cancer research : CR (2023)

T cell function through the upregulation of PD-L1, IL-6 and TGF-β via GPR30-AKT signaling. CYP19A1 inhibition combined with PD-1 blockade represents a promising therapeutic strategy for colon cancer immunotherapy.

Keyphrases

cell proliferation
signaling pathway
fatty acid
poor prognosis
cancer therapy
drug delivery
transforming growth factor