Irciniaplysins A-D: New Psammaplysin Derivatives from Philippine Marine Sponge Ircinia sp.
Aileen May G AngMylene M UyEmi OhtaHisashi ÔmuraShinji OhtaPublished in: Chemistry & biodiversity (2024)
Four new psammaplysin derivatives (1-4) with fatty acyl substituents, designated irciniaplysins A-D, and three known psammaplysins (5-7) were isolated from a marine sponge Ircinia sp. Their structures were elucidated using extensive spectroscopic analyses. The positions of the double bonds and the branch points of the fatty acyl side chains were determined by GC-MS analysis of their fatty acid methyl ester (FAME) derivatives. Irciniaplysins A (1) and B (2) contained an unusual long-chain fatty acyl substituent with a 5,9-diene unit. The isolated compounds were evaluated for their cytotoxic activity against the human colorectal carcinoma (HCT 116) cells, however, none of these compounds showed significant activity.
Keyphrases
- fatty acid
- cell cycle arrest
- induced apoptosis
- endothelial cells
- structure activity relationship
- molecular docking
- cell death
- high resolution
- oxidative stress
- induced pluripotent stem cells
- pi k akt
- mass spectrometry
- signaling pathway
- endoplasmic reticulum stress
- pluripotent stem cells
- molecular dynamics simulations