Rose Bengal Photodynamic Therapy (RB-PDT) Modulates the Inflammatory Response in LPS-Stimulated Human Corneal Fibroblasts By Influencing NF-κB and p38 MAPK Signaling Pathways.
Ning ChaiTanja StachonTim BergerZhen LiMaryam AminiShweta SuiwalBerthold SeitzAchim LangenbucherNóra SzentmáryPublished in: Current eye research (2024)
Rose bengal photodynamic therapy of lipopolysaccharide-stimulated human corneal fibroblasts can modify the inflammatory response by inducing interleukin-6 and interleukin-8 expression, and decreasing intercellular adhesion molecule-1 production. C-C motif chemokine ligand-4, interferon regulatory factor-3, and interferon α and β expressions are not affected by rose bengal photodynamic therapy in these cells. The underlying mechanisms may be associated with nuclear factor kappa B and p38 mitogen-activated protein kinase pathway activation.
Keyphrases
- photodynamic therapy
- inflammatory response
- nuclear factor
- toll like receptor
- lps induced
- lipopolysaccharide induced
- fluorescence imaging
- endothelial cells
- signaling pathway
- induced apoptosis
- poor prognosis
- induced pluripotent stem cells
- dendritic cells
- pi k akt
- optical coherence tomography
- cell cycle arrest
- extracellular matrix
- transcription factor
- pluripotent stem cells
- immune response
- endoplasmic reticulum stress
- oxidative stress
- protein kinase
- cystic fibrosis
- candida albicans