Benchmark of cellular deconvolution methods using a multi-assay reference dataset from postmortem human prefrontal cortex.

Louise A Huuki-Myers Kelsey D Montgomery Sang Ho KwonSophia CinquemaniSean K Maden Nicholas J Eagles Joel E Kleinman Thomas M Hyde Stephanie C Hicks Kristen R Maynard Leonardo Collado-Torres

Published in: bioRxiv : the preprint server for biology (2024)

are the top performing methods with performance dependent on the RNA-seq library preparation conditions. We provide a multi-assay resource for the development and evaluation of deconvolution algorithms.

Keyphrases

rna seq
prefrontal cortex
single cell
high throughput
endothelial cells
machine learning
deep learning
induced pluripotent stem cells
molecularly imprinted