Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy.
Marit J van ElsasCamilla LabrieAnders EtzerodtPornpimol CharoentongJordi J C van Stigt ThansThorbald van HallSjoerd H Van der BurgPublished in: Journal for immunotherapy of cancer (2023)
M2 macrophages are resistant to Csf1r-targeted therapies, in-depth characterization and identification of the underlying mechanisms driving immunotherapy resistance allows the specific targeting of this subset of macrophages, thereby creating new opportunities for therapeutic intervention with the aim to overcome immunotherapy resistance.