Emerging roles of SIRT6 in human diseases and its modulators.
Gang LiuHaiying ChenHua LiuWenbo ZhangJia ZhouPublished in: Medicinal research reviews (2020)
The biological functions of sirtuin 6 (SIRT6; e.g., deacetylation, defatty-acylation, and mono-ADP-ribosylation) play a pivotal role in regulating lifespan and several fundamental processes controlling aging such as DNA repair, gene expression, and telomeric maintenance. Over the past decades, the aberration of SIRT6 has been extensively observed in diverse life-threatening human diseases. In this comprehensive review, we summarize the critical roles of SIRT6 in the onset and progression of human diseases including cancer, inflammation, diabetes, steatohepatitis, arthritis, cardiovascular diseases, neurodegenerative diseases, viral infections, renal and corneal injuries, as well as the elucidation of the related signaling pathways. Moreover, we discuss the advances in the development of small molecule SIRT6 modulators including activators and inhibitors as well as their pharmacological profiles toward potential therapeutics for SIRT6-mediated diseases.
Keyphrases
- small molecule
- oxidative stress
- endothelial cells
- dna repair
- ischemia reperfusion injury
- gene expression
- cardiovascular disease
- induced pluripotent stem cells
- pluripotent stem cells
- signaling pathway
- rheumatoid arthritis
- protein protein
- squamous cell carcinoma
- metabolic syndrome
- multidrug resistant
- climate change
- young adults
- optical coherence tomography
- skeletal muscle
- pi k akt
- induced apoptosis
- squamous cell
- human health
- wound healing
- liver fibrosis
- glycemic control