MT1G induces lipid droplet accumulation through modulation of H3K14 trimethylation accelerating clear cell renal cell carcinoma progression.

Sen WangKexin WangDong YueXiaxia YangXiaozao PanFeifei KongRou ZhaoQingli BieDongxing TianShuqing ZhuBaoyu HeZhang Bin

Published in: British journal of cancer (2024)

Our study unveils a novel mechanism of lipid droplet accumulation in ccRCC, where MT1G inhibits CPT1B expression through modulation of H3K14 trimethylation, consequently enhancing lipid droplet accumulation and promoting ccRCC progression. Graphical abstract figure Schematic diagram illustrating MT1G/H3K14me3/CPT1B-mediated lipid droplet accumulation promoted ccRCC progression via FAO inhibition.

Keyphrases

high throughput
single cell
fatty acid
poor prognosis