Possible role of intestinal fungal dysbiosis in dectin-1 and cytokines expression in patients with ulcerative colitis.
Negin AzizollahNiusha SharifinejadSayed-Hamidreza MozhganiSeyed Mehdi MousavianMahmoud BakhtiyariElaheh MahmoudiPublished in: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology (2024)
The current study revealed a possible role for intestinal fungi to promote colonic inflammation and increase UC activity through Dectin-1 stimulation. A positive correlation was detected between intestinal fungal richness with UC susceptibility and activity. IL-4 and IL-10 were associated with disease activity. Besides, the expression levels of Dectin-1, IL-17 and IL-22 were independently associated with disease activity.