Dual-Hit Strategy for Therapeutic Targeting of Pancreatic Cancer in Patient-Derived Xenograft Tumors.
Tista Roy ChaudhuriQingxiang LinEwa K StachowiakSpencer R RosarioJoseph A SpernyakWen Wee MaMichal K StachowiakMichelle K GreeneGerard P QuinnSimon S McDadeMartin ClynesChristopher J ScottRobert M StraubingerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
This dual-hit strategy of SMO and FGFR inhibition provides a clinically-translatable approach to compromise the profound impermeability of PDAC tumors. Furthermore, clinical deployment of DW-MR imaging could fulfill the essential clinical-translational requirement for patient stratification.