Implementation of an adapted Sepsis Risk Calculator algorithm to reduce antibiotic usage in the management of early onset neonatal sepsis: a multicentre initiative in Wales, UK.

Nitin GoelStephanie CannellGemma DaviesMurali Sridhar NattiVickness KirupaalarArtur AbelianShakir SaeedRhian SmithRavi ManikondaPrem Kumar PitchaikaniDawn DaviesRachel May MorrisLynsey EdwardsRoopashree GovindarajuKate CreeseJane JonesJalil ChoudharySarah RowleyChidambaram SethuramanHelen MuxworthyFelicity CurtisPatricia DonnellyManohar JoishyIan BarnardCelyn KennyRajarshi PalKaren JonesSujoy Banerjee

Published in: Archives of disease in childhood. Fetal and neonatal edition (2021)

This multicentre study provides evidence that a judicious adaptation of the SRC incorporating enhanced surveillance can be safely introduced in the National Health Service and is effective in reducing antibiotic use for EONS without increasing morbidity and mortality.

Keyphrases

early onset
quality improvement
septic shock
late onset
acute kidney injury
intensive care unit
primary care
public health
machine learning
cross sectional
healthcare
clinical trial
tyrosine kinase
study protocol
randomized controlled trial
neural network