Antidiarrheal effect of Psidium guajava L. extract in acute diarrhea: a systematic review.
Gabino GarridoBárbara B Garrido-SuárezNicolás Martínez TapiaMarisela Valdés-GonzálezAndrea Ortega-MardonesPublished in: Journal of the science of food and agriculture (2024)
Twenty-three articles were included. Twenty (87%) of theirs reported heterogenic preclinical studies, predominating pharmacological studies of efficacy against conventional antidiarrheal agents, which utilized relevant outcomes and models of infectious diarrhea from the top pathogens in the clinic along with classical castor oil-induced diarrhea associated with motility tests. Only three of them (13%) corresponded to clinical trials to study the efficacy, dose, and safety of these preparations. Most studies reported positive results and significant mechanistic evidence from antibacterial, anti-motility, anti-secretory, and protective/anti-inflammatory perspectives. However, further studies are needed to define the clinical significance and safety treatment with P. guajava extracts. This article is protected by copyright. All rights reserved.
Keyphrases
- anti inflammatory
- case control
- clinical trial
- irritable bowel syndrome
- primary care
- oxidative stress
- stem cells
- intensive care unit
- randomized controlled trial
- diabetic rats
- adipose tissue
- metabolic syndrome
- cell therapy
- endothelial cells
- fatty acid
- weight loss
- cystic fibrosis
- multidrug resistant
- silver nanoparticles
- candida albicans
- high glucose
- phase iii