Genomic characterization of human respiratory syncytial virus circulating in Islamabad, Pakistan, during an outbreak in 2022-2023.
Syed Adnan HaiderZunera JamalFaheem TahirMuhammad SalmanMassab UmairPublished in: Archives of virology (2024)
In this study, conducted at the National Institute of Health, Islamabad, during an outbreak of human respiratory syncytial virus (hRSV) from December 2022 to January 2023, the first whole-genome sequences of hRSV isolates from Islamabad, Pakistan, were determined. Out of 10 positive samples, five were sequenced, revealing the presence of two genotypes: RSV-A (GA2.3.5, ON1 strain) and RSV-B (GB5.0.5.a, BA-10 strain). A rare non-synonymous substitution (E232G) in G the protein and N276S in the F protein were found in RSV-A. In RSV-B, the unique mutations K191R, Q209R, and I206M were found in the F protein. These mutations could potentially influence vaccine efficacy and viral pathogenicity. This research underscores the importance of genomic surveillance for understanding RSV diversity and guiding public health responses in Pakistan.
Keyphrases
- respiratory syncytial virus
- public health
- endothelial cells
- protein protein
- healthcare
- tertiary care
- amino acid
- induced pluripotent stem cells
- pet ct
- copy number
- sars cov
- pluripotent stem cells
- binding protein
- mental health
- global health
- biofilm formation
- dna methylation
- climate change
- escherichia coli
- pseudomonas aeruginosa
- health information