Association of tau accumulation and atrophy in mild cognitive impairment: a longitudinal study.

Gang XuShuzhan ZhengZhilong ZhuXiaofeng YuJian JiangJuanjuan JiangZhaohu Chunull null

Published in: Annals of nuclear medicine (2020)

Our findings provide a preliminary description of the patterns of longitudinal FTP accumulation and annualized cortical atrophy in MCI progression, and MCI subjects with high tau binding levels show an increase risk of longitudinal tau accumulation, atrophy, and cognitive decline. Trial registration NCT00106899. Registered 1 April 2005, https://clinicaltrials.gov/ct2/show/study/NCT00106899.

Keyphrases

mild cognitive impairment
cognitive decline
cerebrospinal fluid
cross sectional
computed tomography
clinical trial
image quality
randomized controlled trial
phase iii
dna binding