GPETAFLR, a peptide from Lupinus angustifolius L. prevents inflammation in microglial cells and confers neuroprotection in brain.
Ana Lemus-ConejoMaría Del Carmen Millán-LinaresRocio ToscanoFrancisco MillanJusto PedrocheFrancisco J G MurianaSergio Montserrat-de la PazPublished in: Nutritional neuroscience (2020)
This is the first report describing that a peptide from plant origin robustly restrained the pro-inflammatory activation of microglial cells in cultures and in brain. Our data suggest that GPETAFLR might be instrumental in maintaining CNS homeostasis by inhibiting neuroinflammation.
Keyphrases
- induced apoptosis
- lipopolysaccharide induced
- cell cycle arrest
- cerebral ischemia
- lps induced
- oxidative stress
- inflammatory response
- signaling pathway
- white matter
- resting state
- endoplasmic reticulum stress
- traumatic brain injury
- blood brain barrier
- functional connectivity
- spinal cord injury
- cell proliferation
- machine learning
- spinal cord
- big data
- cell wall