Influence of Biological Therapeutics, Cytokines, and Disease Activity on Depression in Rheumatoid Arthritis.
Margarida Figueiredo-BragaCaleb CornabyAlice CortezMiguel BernardesGeorgina TerrosoMarta FigueiredoCristina Dos Santos MesquitaLúcia CostaBrian D PoolePublished in: Journal of immunology research (2018)
A variety of both biological and social factors influences depressive symptoms in RA. IL-10 and IL-6 are likely to be involved, since IL-10 concentration was associated with depression and Tocilizumab decreased depressive symptoms in the RA patients. The roles of these cytokines are different in RA and lupus, as high IL-10 in RA is associated with increased depressive symptoms, but high IL-10 in the lupus patients is associated with decreased depression. IL-6 was also associated with depressive symptoms in the patients with primary depression. These results strongly indicate that disease activity, including cytokine levels, has a strong impact on depressive symptoms.
Keyphrases
- disease activity
- depressive symptoms
- rheumatoid arthritis
- systemic lupus erythematosus
- rheumatoid arthritis patients
- ankylosing spondylitis
- social support
- sleep quality
- juvenile idiopathic arthritis
- end stage renal disease
- ejection fraction
- newly diagnosed
- interstitial lung disease
- peritoneal dialysis
- mental health
- small molecule