Anti-obesity effects of yuja (Citrus junos Sieb ex Tanaka) pomace extract fermented with lactic acid bacteria on the hepatocytes and epididymal fat tissue of rats.
Han-Na ChuHaeng-Ran KimKyeong-A JangYu-Jin HwangJeong-Sang KimPublished in: Applied microscopy (2023)
This study investigated the anti-obesity effects of yuja pomace extract fermented with lactic acid bacteria in rats with high-fat diet-induced obesity over a period of eight weeks. Epididymal fat cell size was significantly smaller, by about 33%, in the treatment groups given yuja pomace extract fermented with lactic acid bacteria compared to the CON group. Electron microscopic observation of hepatocyte microstructure showed that the number of lipid droplets was lower in hepatocytes, the number of mitochondria was higher, along with distinct cristae, and the rough endoplasmic reticula were well developed with stacks of cisternae and ribosomes. Thus, it is believed that yuja pomace extract fermented with lactic acid bacteria, by influencing body weight and lipid accumulation, is effective in the prevention and treatment of obesity.
Keyphrases
- lactic acid
- high fat diet induced
- insulin resistance
- metabolic syndrome
- weight loss
- adipose tissue
- body weight
- type diabetes
- oxidative stress
- weight gain
- skeletal muscle
- anti inflammatory
- fatty acid
- cell death
- multiple sclerosis
- cell therapy
- combination therapy
- high resolution
- atomic force microscopy
- mesenchymal stem cells
- preterm birth