A Chemotherapy-Driven Increase in Mcl-1 Mediates the Effect of miR-375 on Cisplatin Resistance in Osteosarcoma Cells.

An-Song LiuHai-Yang YuYan-Lin YangFu-Yao XueXia ChenYun ZhangZi-Yu ZhouBin ZhangLan LiChuan-Zheng SunPeng HuangJu-Fang Huang

Published in: OncoTargets and therapy (2019)

Our data indicated that chemotherapy-driven increase in the expression of Mcl-1 plays a critical role in chemoresistance, and the intervention of the miR-375/Mcl-1 axis may offer a novel strategy to enhance chemosensitivity in OS treatment.

Keyphrases

long non coding rna
cell proliferation
poor prognosis
long noncoding rna
induced apoptosis
locally advanced
randomized controlled trial
cell cycle arrest
electronic health record
squamous cell carcinoma
chemotherapy induced
radiation therapy
replacement therapy
smoking cessation