High Frequency of Viral Co-Detections in Acute Bronchiolitis.
Hortense PetatVincent GajdosFrançois AngoulvantPierre-Olivier VidalainSandrine CorbetChristophe MarguetJacques BrouardAstrid VabretMeriadeg Ar GouilhPublished in: Viruses (2021)
Over two years (2012-2014), 719 nasopharyngeal samples were collected from 6-week- to 12-month-old infants presenting at the emergency department with moderate to severe acute bronchiolitis. Viral testing was performed, and we found that 98% of samples were positive, including 90% for respiratory syncytial virus, 34% for human rhino virus, and 55% for viral co-detections, with a predominance of RSV/HRV co-infections (30%). Interestingly, we found that the risk of being infected by HRV is higher in the absence of RSV, suggesting interferences or exclusion mechanisms between these two viruses. Conversely, coronavirus infection had no impact on the likelihood of co-infection involving HRV and RSV. Bronchiolitis is the leading cause of hospitalizations in infants before 12 months of age, and many questions about its role in later chronic respiratory diseases (asthma and chronic obstructive pulmonary disease) exist. The role of virus detection and the burden of viral codetections need to be further explored, in order to understand the physiopathology of chronic respiratory diseases, a major public health issue.
Keyphrases
- respiratory syncytial virus
- sars cov
- high frequency
- chronic obstructive pulmonary disease
- emergency department
- public health
- transcranial magnetic stimulation
- endothelial cells
- lung function
- clinical trial
- randomized controlled trial
- respiratory syndrome coronavirus
- respiratory tract
- high intensity
- intensive care unit
- cystic fibrosis
- induced pluripotent stem cells
- respiratory failure
- loop mediated isothermal amplification
- study protocol
- pluripotent stem cells
- hepatitis b virus