Quantification of changes in human islet G protein-coupled receptor mRNA expression in obesity.
Zekun LyuMin ZhaoPatricio AtanesShanta Jean PersaudPublished in: Diabetic medicine : a journal of the British Diabetic Association (2022)
Under conditions of obesity, human islets showed significant alterations in mRNAs encoding numerous GPCRs. The increased expression of Gαs- and Gαq-coupled receptors that have not previously been investigated in β-cells opens up possibilities of novel therapeutic candidates that may lead to the potentiation of insulin secretion and/or β-cell mass to regulate glucose homeostasis.
Keyphrases
- endothelial cells
- metabolic syndrome
- insulin resistance
- weight loss
- induced apoptosis
- pluripotent stem cells
- weight gain
- poor prognosis
- single cell
- cell therapy
- body mass index
- stem cells
- adipose tissue
- binding protein
- bone marrow
- oxidative stress
- signaling pathway
- cell proliferation
- mesenchymal stem cells
- mass spectrometry
- single molecule