Expression of Genes Related to Lipid Handling and the Obesity Paradox in Melanoma: Database Analysis.

Claudia Giampietri Luana Tomaipitinca Francesca Scatozza Antonio Facchiano

Published in: JMIR cancer (2020)

The observed lower expression of genes such as CD36 and FABP4 in melanoma may reduce the cellular internalization of fat and therefore make patients with melanoma less sensitive to a high dietary fat intake, explaining in part the obesity paradox observed in patients with melanoma.

Keyphrases

poor prognosis
skin cancer
insulin resistance
metabolic syndrome
weight gain
weight loss
adipose tissue
binding protein
type diabetes
genome wide
fatty acid
high fat diet induced
basal cell carcinoma
emergency department
long non coding rna
bioinformatics analysis