Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study.
Rodrigo PessôaDaniela Raguer Valadão de SouzaYouko NukuiJuliana PereiraLorena Abreu FernandesRosa Maria do Nascimento MarcussoAugusto César Penalva de OliveiraJorge Simão do Rosário CassebAlberto José da Silva DuarteSabri Saeed SanabaniPublished in: International journal of molecular sciences (2023)
Small RNAs (sRNAs) are epigenetic regulators of essential biological processes associated with the development and progression of leukemias, including adult T-cell leukemia/lymphoma (ATLL) caused by human T-cell lymphotropic virus type 1 (HTLV-1), an oncogenic human retrovirus originally discovered in a patient with adult T-cell leukemia/lymphoma. Here, we describe the sRNA profile of a 30-year-old woman with ATLL at the time of diagnosis and after maintenance therapy with the aim of correlating expression levels with response to therapy.