A systematic review of non-coding RNA genes with differential expression profiles associated with autism spectrum disorders.
Jon StottThomas WrightJannah HolmesJulie WilsonSam Griffiths-JonesDeborah FosterBarry WrightPublished in: PloS one (2023)
There is limited but promising evidence associating the expression of certain miRNA genes and ASD, although the studies are of variable methodological quality and the results are largely inconsistent. There is emerging evidence associating differential expression of snoRNA genes in ASD. It is not currently possible to say whether the reports of differential expression in ncRNA may relate to ASD aetiology, a response to shared environmental factors linked to ASD such as sleep and nutrition, other molecular functions, human diversity, or chance findings. To improve our understanding of any potential association, we recommend improved and standardised methodologies and reporting of raw data. Further high-quality research is required to shine a light on possible associations, which may yet yield important information.
Keyphrases
- autism spectrum disorder
- attention deficit hyperactivity disorder
- intellectual disability
- genome wide
- bioinformatics analysis
- genome wide identification
- endothelial cells
- physical activity
- poor prognosis
- adverse drug
- quality improvement
- big data
- transcription factor
- binding protein
- health information
- pluripotent stem cells
- induced pluripotent stem cells