Function of TRPC1 in modulating hepatocellular carcinoma progression.
Huimin QiFengming WuHongmei WangPublished in: Medical oncology (Northwood, London, England) (2023)
The liver is the main organ of metabolism in the human body, and it is easy to suffer from hepatitis, cirrhosis, liver cancer, and other diseases, the most serious of which is liver cancer. Worldwide, liver cancer is the most common and deadly malignant tumor, the third leading cause of cancer death in the world. Based on TCGA and ICGC databases, our research discovered the important role of TRPC1 in liver cancer through bioinformatics. The results showed that TRPC1 was over-expressed in hepatocellular carcinoma, and the higher the expression level of TRPC1, the worse the OS and the lower the survival rate. TRPC1 was a risk factor affecting the overall survival probability of hepatocellular carcinoma patients. By analyzing the function of the TRP family in liver cancer, TRPC1 might promote the occurrence of liver cancer by up-regulating common signal pathways in tumors such as tumor proliferation signature, and down-regulating important metabolic reactions such as retinol metabolism. In addition, TRPC1 could promote the development of liver cancer by up-regulating the expression of ABI2, MAPRE1, YEATS2, MTA3, TMEM237, MTMR2, CCDC6, AC069544.2, and NCBP2 genes. These results illustrate that TRPC1 is very valuable in the study of liver cancer.
Keyphrases
- vascular smooth muscle cells
- poor prognosis
- risk factors
- signaling pathway
- end stage renal disease
- endothelial cells
- risk assessment
- gene expression
- squamous cell carcinoma
- machine learning
- prognostic factors
- free survival
- deep learning
- big data
- dna methylation
- genome wide
- artificial intelligence
- peritoneal dialysis
- induced pluripotent stem cells
- pluripotent stem cells