The Rheumatoid Arthritis Gene Expression Signature Among Women Who Improve or Worsen During Pregnancy: A Pilot Study.
Amogh PathiMatthew WrightMette Kiel SmedJ Lee NelsonJørn OlsenMerete Lund HetlandVibeke ZoffmannDamini JawaheerPublished in: The Journal of rheumatology (2020)
In our pilot dataset, pre-pregnancy RA expression signatures differed between women who subsequently improved or worsened during pregnancy, suggesting that inherent genomic differences may influence how pregnancy affects disease activity. Further, these RA signatures were altered during pregnancy as disease activity changed.
Keyphrases
- disease activity
- rheumatoid arthritis
- pregnancy outcomes
- systemic lupus erythematosus
- rheumatoid arthritis patients
- gene expression
- ankylosing spondylitis
- polycystic ovary syndrome
- juvenile idiopathic arthritis
- preterm birth
- pregnant women
- genome wide
- poor prognosis
- dna methylation
- interstitial lung disease
- cervical cancer screening
- clinical trial
- copy number
- metabolic syndrome
- adipose tissue
- binding protein
- systemic sclerosis