Rehabilitation for Functioning and Quality of Life in Patients with Malignant Pleural Mesothelioma: A Scoping Review.
Lorenzo LippiAlessandro de SireVittorio AprileDario CalafioreArianna FolliFjorelo RefatiAndrea BalduitAlessandro MangognaMariia IvanovaKonstantinos VenetisNicola FuscoMarco InvernizziPublished in: Current oncology (Toronto, Ont.) (2024)
Malignant pleural mesothelioma (MPM) represents a significant clinical challenge due to limited therapeutic options and poor prognosis. Beyond mere survivorship, setting up an effective framework to improve functioning and quality of life is an urgent need in the comprehensive management of MPM patients. Therefore, this study aims to review the current understanding of MPM sequelae and the effectiveness of rehabilitative interventions in the holistic approach to MPM. A narrative review was conducted to summarize MPM sequelae and their impact on functioning, disability, and quality of life, focusing on rehabilitation interventions in MPM management and highlighting gaps in knowledge and areas for further investigation. Our findings showed that MPM patients experience debilitating symptoms, including fatigue, dyspnea, pain, and reduced exercise tolerance, decreasing quality of life. Supportive and rehabilitative interventions, including pulmonary rehabilitation, physical exercise improvement, psychological support, pain management, and nutritional supplementation, seem promising approaches in relieving symptoms and improving quality of life but require further research. These programs emphasize the pivotal synergy among patient-tailored plans, multidisciplinary team involvement, and disease-specific focus. Despite advancements in therapeutic management, MPM remains a challenging disease with limited effective interventions that should be adapted to disease progressions. Rehabilitative strategies are essential to mitigate symptoms and improve the quality of life in MPM patients. Further research is needed to establish evidence-based guidelines for rehabilitative interventions tailored to the unique needs of MPM patients.
Keyphrases
- end stage renal disease
- ejection fraction
- pain management
- poor prognosis
- chronic kidney disease
- newly diagnosed
- physical activity
- randomized controlled trial
- prognostic factors
- systematic review
- chronic pain
- healthcare
- spinal cord injury
- multiple sclerosis
- sleep quality
- palliative care
- young adults
- patient reported
- pulmonary hypertension
- public health
- patient reported outcomes
- health insurance
- quality improvement
- smoking cessation