Multiplex Tissue Imaging Harmonization: A Multicenter Experience from CIMAC-CIDC Immuno-Oncology Biomarkers Network.

Guray Akturk Edwin Roger Parra Cuentes Evisa GjiniAna LakoJiun-Kae Jack Lee Donna S Neuberg Jianhua ZhangShen YaoIlaria LafaceAnita RogicPei-Hsuan ChenBeatriz Sanchez-EspiridionDiane M Del ValleRadim MoravecRobert KindersCourtney W Hudgens Catherine J WuIgnacio I WistubaMagdalena ThurinStephen M HewittScott RodigSacha GnjaticMichael T Tetzlaff

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Our results support interchangeability of protocols and platforms to deliver robust, and comparable data using similar tissue specimens and confirm that CIMAC-CIDC analyses may therefore be used with confidence for statistical associations with clinical outcomes largely independent of site, antibody selection, protocol, and platform across different sites.

Keyphrases

high throughput
randomized controlled trial
high resolution
palliative care
electronic health record
big data
cross sectional
machine learning
fluorescence imaging