Early Postnatal Changes of Bone Turnover Biomarkers in Very Low-Birth-Weight Neonates-The Effect of Two Parenteral Lipid Emulsions with Different Polyunsaturated Fatty Acid Content: A Randomized Double-Blind Study.

Panos PapandreouCharalampos AgakidisMaria ScouroliakouThomais Karagiozoglou-LampoudiAdriana KalioraNick KalogeropoulosTania Siahanidou

Published in: JPEN. Journal of parenteral and enteral nutrition (2019)

A high bone-turnover rate in VLBW neonates with predominance of bone resorption is confirmed. The lower rate of OPG/sRANKL reduction in the n-3-enriched PLE group indicates that n-3 PUFA-enriched PLEs may help to attenuate early bone loss in VLBW neonates.

Keyphrases

low birth weight
bone loss
preterm infants
fatty acid
bone mineral density
human milk
preterm birth
double blind
body composition
soft tissue
clinical trial
bone regeneration
study protocol
randomized controlled trial